Man United top Europa League

first_imgSTOCKHOLM, Sweden (AP): Manchester United gave their grieving home city a moment to cheer by winning the Europa League yesterday, beating Ajax 2-0 in the final thanks to goals by Paul Pogba and Henrikh Mkhitaryan. Pogba pointed to the sky as he was mobbed by teammates after his 18th-minute opening goal. The game was played two days after 22 people were killed in a bomb attack at a concert in Manchester, and 12 days after the death of Pogba’s father, Fassou Antoine. Mkhitaryan scored the second goal in the 48th minute, hooking the ball in from close range from a corner. The win earned United the bonus prize of a place in next season’s Champions League and meant coach Jose Mourinho finished his first season at England’s biggest club with two trophies. United also won the English League Cup in February. United’s players flew to Sweden in a sombre mood and with heavy hearts following the tragedy at an Ariana Grande concert on Monday, and were determined to produce a display that served as a tribute to the victims and their families. That they succeeded in doing so was a testament to their strength of character. The planned pre-match one minute’s silence in honour of the victims rapidly turned into 60 seconds of applause, during which United’s fans chanted “Manchester, Manchester”. Both teams wore black armbands for the match in another mark of respect and both sets of fans came together, mingling happily outside the stadium and in the city centre before the match. The game was billed as a clash between the pragmatism of Mourinho’s United against the swagger and youthful exuberance of an Ajax side featuring six players aged 21 or under and in the club’s first European final in 21 years. STRENGTH OF CHARACTERlast_img read more

August date for Ashley’s world title fight

first_imgA date in early August is likely for the return World Boxing Council (WBC) world title fight between champion Fatuma Zarika from Kenya and Jamaica’s Alicia Ashley, the former champion. This was disclosed to The Sunday Gleaner yesterday by promoter Luigi Olcese, who also said that the venue would be El Paso, Texas. Zarika and Ashley met on October 1 last year in Michigan, USA, and Zarika dethroned the champion by way of a controversial, 10-round split decision. They had agreed to a return fight in case Ashley lost, however, and Olcese said that this is now being enforced. “There have been some hiccups in arranging the return fight, but I think everything is now sorted out, and we are pretty close to finalising all the details,” he said. Continuing, Olcese said that he had looked at several venues, including Jamaica, for the return fight, but Texas turned out to be the best option. “Alicia really wanted to fight in Jamaica, but I just could not get things sorted out there, but, hopefully, she regains the title, and in that case, Jamaica will, of course, be on the top of the list of possible venues,” he continued. Ashley, in the meantime, is anxious to get back into the ring for the return fight. She told The Sunday Gleaner that she was already in training for the fight and had shifted her training venue from New York to Florida. “I am taking this fight very seriously as I want to regain my title. I have moved my training camp to Fort Lauderdale so as to avoid distractions. It is a costly decision for me, but I want to focus on nothing but this fight, and this is the best thing for me now. I have to be in top condition, and nothing is going to stand in my way,” she added. She, too, expressed her disappointment that the fight would not be taking place in Jamaica but added: “The good thing is that after I regain my title, the venue for my first fight after that must be Jamaica.”last_img read more

Guyana is on its own

first_imgDear Editor,Though this may be an obvious point to the analyst community, it is important that the wider Guyanese community understand that multinational companies such as Exxon, registers their investment vehicles in a low-corporation tax jurisdiction, and not in the country where their headquarters are situated for a specific reason; to cap their financial exposure per project.The investment in Guyana is owned by Esso Exploration and Production Guyana Limited (Esso) which was incorporated in the Bahamas. Similarly, the Chinese partner in this Guyana investment, CNOOC which is headquartered in Beijing, China is also not exposed because the vehicle fronting for them is called CNOOC Nexen Petroleum Guyana Limited, which was incorporated in Barbados. Same thing for Hess Corporation which is headquartered in New York City, but their Guyana vehicle is incorporated in the Cayman Islands.So if this oil spill happens (the divine forbid), then the people of Guyana will be allowed to sue for restitution. But from whom? They cannot sue these headquarters because legally they are ring fenced from the entire transaction. If Guyana sues in the US Courts, there is already a precedence set where the 2nd US Circuit Court of Appeal, in New York, in 2016, blocked the enforcement of an US$8.6 billion judgement against Chevron, over oil pollution in Ecuador. The bottom line remains that these multi-nationals have a template for avoiding legal accountability anywhere in the world.The only parties Guyana can successfully sue and enforce against are the Bahamian, Barbadian and Cayman Island companies, but they are what you call shell companies with limited finite assets on their books.The sole purpose of these shell companies is to pay the bills out of the earned income generated from the waters of Guyana. In short, if it happens, Guyana’s available oil profits will be paying for Guyana’s oil spill, and if it becomes zero at any point in time, then we are on our own.Multinational companies usually just keep a small fraction of their profits in the local investment vehicle. They use a mechanism in finance called transfer pricing to move significant portions of those profits out of the local books, and into other books that Guyana cannot, and will not be able to make a claim against. How do they do it? All sorts of high priced oil consultancies and oil services contracts will be signed between the Guyana investment vehicle and agents of the three respective headquarters for services rendered while keeping the legal entities separate and distinct (ring fenced). The disadvantage to Guyana from such a situation, is that the headquarters of these three partners can pull cash out of the Guyana investment vehicle as they see fit, but the Guyana’s investment vehicle has no power to access any of the cash from these headquarters if things go wrong.The bottom line, if one carefully reads this Petroleum Agreement between the Government of Guyana and these Investors, is that they will find enough clauses to support a position that if any mishap occurrs at the production site, Guyana is on its own. For emphasis, let me reiterate – Guyana is on its own if things go wrong in the oil operations.Therefore, how prepared is Guyana at cleaning up its ocean front if an oil spill happens, the divine forbids? Is the EPA ready? Is the Maritime Authority ready? Is there any institution in Guyana ready for this eventuality? Will they be ready by 2020? It is time for Guyana to plead its case to the Americans, British, Canadians, European Union, and any country who has the competence and skill to help so that we can properly fund, equip, train and establish a Coastal Environmental Unit in the EPA. This reality does not need a rocket scientist to fix, but time is of the essence. The new Head of the EPA, Dr Vincent Adams is a very capable man who is exposed from his time in the US Department of Energy– let us put him to work at sourcing these funds.Sasenarine Singh,Maryland, USAlast_img read more

Scott family aces Karen Dasani round

first_imgJames, 20, the youngest member of the team, anchored them to victory with one-over par gross score of 39 points.He made a birdie on the second, but dropped shots on the par-four fourth and ninth holes to finish one over on the opening nine holes.On the back nine, James was erratic off the tee, securing birdies on the 11th, 14th and 15th and bogeys on the short par-four 12th and on the 16th and 17th for a level par score.His parents, Hugh and Alastair played steady golf, scoring 37 points each for a team total of 113 points.Alastair, a recent university graduate and easily one of the longest golf-ball hitters on the continent, hit it long and wrong throughout the afternoon finishing with a miserable 28 to claim the infamous title of weakest-link.Defending his performance, Alastair said it was his dad’s fault. “I have been under pressure with my studies and my dad has been encouraging me to study more and play less,” Alastair said. “But I will come right at the Grand Finale and ensure that we win the grand prize.”Speaking at the prize giving ceremony, Hugh, a consultant with the Africa Enterprise Challenge Fund, said his family’s dedication pushed them forward.“I’m absolutely grateful to my family. We stayed focused and in the end our team effort paid off,” he added: “That was a fantastic tournament here at Karen and we’re working towards coming back in the Grand Finale as the best.”The team of Peter Kanyago, John Muiruri, Kingori Kariuki and Steve Waruhiu finished second with 112, one shy of the winners.Kariuki anchored the team with 41, Waruhiu 38 and Muiruri contributed 33 for a team total of 112.Kanyago, the Kenya Open Golf Ltd Chairman was the team’s weakest link with 29.George Muturi, Joe Muigai, Ken Kubasu and Peter Waweru finished third with 107 with the latter also claiming the overall individual prize with 43 points, a 2-under par gross score of 70, probably the golf round of his life.Frederick Kariuki, Joe Kihanya, Stanley Nduati and Irungu Wanyoike finished fourth with 106.These four teams will represent the Karen Country Club at the Dasani Golf Gala Grand Finale on the August 27 at the same venue.The winning team at the Grand Finale will win a VIP trip to PGA TOUR Championship, presented by Coca-Cola, at the East Lake Golf Club in Atlanta, the home of Coca-Cola..0Shares0000(Visited 1 times, 1 visits today) 0Shares0000NAIROBI, Kenya, July 31- The Scott family scored 113 points to top the 13th round of the 2011 Dasani Gold Gala held at the par-72 Karen Country Club.Father Hugh, mother Hilary and their sons Alastair and James mastered the 18-hole course to secure one of four coveted spots in the Golf Gala Grand Finale.last_img read more

Wonder bread baker to slice 1,300 local jobs

first_imgKANSAS CITY, Mo. _ Interstate Bakeries Corp., the maker of Wonder bread and Hostess Twinkies, said Tuesday it will exit the bread business in Southern California, cutting about 1,300 jobs. The Kansas City-based company, in Chapter 11 bankruptcy protection since 2004, said it will close four bakeries in Glendale, Pomona, San Diego and Los Angeles. It will also consolidate about 325 distribution routes and close 17 distribution centers and 19 outlet stores. Interstate Bakeries said the moves, which require approval by a bankruptcy court judge and the company’s lenders, should be completed by Oct. 29 and will require $29.2 million in charges and an additional $1.8 million in accrued expenses. “While IBC has made marked progress in several problem markets over the last six months, bread operations in Southern California continue to be unprofitable,” Craig Jung, the company’s chief executive, said in a news release. Jung said the company has struggled in the region with low-cost competitors, changing consumer demand and labor problems. However, the company said it will continue selling Hostess and Dolly Madison branded snack cakes and doughnuts in the area. “We must stop reinforcing failure and press harder where there is success,” he said. The cuts, equal to about 5 percent of the company’s remaining employees, come as Interstate Bakeries continues to seek a path out of almost three years of bankruptcy protection. In that time, the company has slashed its work force by 22 percent and shut down 10 bakeries and numerous distribution centers and thrift stores. It has lost a combined $620 million over the past three fiscal years. Interstate Bakeries has run into an impasse as it seeks concessions from unions that represent 82 percent of its 25,000 employees. Chiefly, Jung wants to move the company from its current distribution method where delivery drivers also sell products to a “path-to-market” system, in which distribution and sales are more separate. The company said path-to-market gives salespeople more time to work with store managers to merchandise the products instead of simply delivering them. It also would allow some customers to order products over the phone or Internet, cutting down on distribution expenses. The International Brotherhood of Teamsters has criticized the plan in a letter to its 10,000 Interstate Bakeries members _ many of whom could be affected by changes in delivery policies _ saying that other companies have tried and later abandoned similar distribution methods and that it has yet to be tried in the baking industry. “We do not share IBC’s view that its business plan will allow the company to emerge from bankruptcy; nor do we agree that IBC’s untested Path-to-Market delivery system is the only way for the company to survive,” Richard Volpe, the Teamster’s international director, said in the Aug. 22 letter. Sandi Sternberg, an Interstate Bakeries spokeswoman, responded that Jung and other members of company management have implemented path-to-market at other companies with success. “IBC’s distribution system has not fundamentally changed in 75 years and has failed to account for both advances in technology and changes in grocery store and consumer preferences,” Sternberg said. “We believe our path-to-market system can give us a huge competitive advantage by meeting the grocery industry’s desire for high-quality, seven-day-week service.” Volpe also said the union has suggested a number of ways to cut other operations, which it said would save the company $295 million over five years. But Jung on Tuesday warned that the company is running out of time. It has until Oct. 5 to propose a reorganization plan or anyone else can make a proposal, including selling the company. “We have weeks, not months or years, to act,” Jung said. “Union agreement to path-to-market and the health and welfare concessions in our business plan are crucial.” Shares of Interstate Bakeries, which trade on the over-the-counter market, were up 10 cents at $1.20 in late morning trading Tuesday.160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set!last_img read more

Chelsea FC team news: Predicted XI to face Southampton – Terry dropped?

first_img 19. Diego Costa (forward) 11 24. Gary Cahill (centre-back) 11 11 28. Cesar Azpilicueta (right wing-back) 10. Eden Hazard (forward) 11 Chelsea will be aiming to make it four Premier League wins on the bounce when they travel to Southampton on Sunday.Antonio Conte’s men bounced back from consecutive defeats in September – to Liverpool and Arsenal – by seeing off Hull City, champions Leicester and Jose Mourinho’s Manchester United.Despite this, the Blues will also be hoping they can bounce back from their EFL Cup defeat at West Ham in week, where crowd trouble marred the round of 16 tie.The Italian boss made changes for the trip to the London Stadium, with the likes of John Terry, Ola Aina, Michy Batshuayi and Nathaniel Chalobah coming into the side.But, providing his side remain injury free, it is unlikely Conte will alter his side too much from their last three Premier League outings, where he has changed to a 3-4-3 formation with flying full-backs.They face a Saints side who have started strongly under Claude Puel in the league and Europa League, with the south coast side unbeaten in their last five league matches.So, who will start at St Mary’s?Click the right arrow, above, to see Chelsea’s predicted XI for Sunday’s match, kick off 4pm UK time – in a 3-4-3 formation – in squad number order. 3. Marcos Alonso (left wing-back) – click the right arrow, above, to see who could start for Chelsea at St Mary’s, in squad number order 11 11 13. Thibaut Courtois (goalkeeper) 11 21. Nemanja Matic (midfield) 11 15. Victor Moses (right wing-back) 11 22. Willian (forward) 7. N’Golo Kante (midfield) 11 30. David Luiz (centre-back) 11last_img read more

Report: Your Company’s Web Apps Are Actually Gaping Security Holes

first_imgWeb applications are still one of the greatest threat to enterprise security, according to Hewlett-Packard’s 2011 mid-year enterprise security risk report. This is no surprise, considering we saw data from Imperva in July that shows Web apps are probed or attacked at least once every two minutes. What is surprising is that enterprises have been slow to recognize and patch vulnerabilities, giving malicious hackers ample opportunity to penetrate their networks.Weaknesses in Web applications make up 31% of all vulnerabilities, according to HP. Technically, reports of Web app vulnerabilities have gone down in recent years, but that is not necessarily a good thing. Legacy Web apps still provide a great risk to enterprise security.A lot of what HP presents in its report will not be new to security professionals. Every single security company and its long lost second cousin has a mid-year security report. For instance, did you know that cross-site scripting (XSS) is the compromises the most significant Web app vulnerability? Or that buffer overflow and Distributed Denial of Service (DDoS) attacks are the second and third most used vulnerabilities? If you are in the security industry, you certainly did know that. SQL injection (SQLi) attacks are very popular among “hacktivist” groups like LulzSec and Anonymous. Booz Allen Hamilton’s recent email leak was mostly SQLi related. The prevalence of SQLi attacks is laughable. Worming an SQL attack into a company’s server should be fairly simple to stop with a layered security approach that stops the data injection with firewalls or data sandboxes within the servers. It is a popular attack because it works. It works because enterprises either do not know what they are protecting against or have been too negligent in updating their security policies. Check out HP’s entire report here (PDF). What can enterprises do to close the gap between legacy vulnerabilities and Web application usage? As we have seen, the attack surface is wide, like a stretched-out cloth that can easily be penetrated by hackers who know what they are looking for. As Web apps become more critical to critical business functions, how can IT managers and the security industry shrink the amount of avenues that malicious hackers use to gain access to sensitive information? 8 Best WordPress Hosting Solutions on the Market Why Tech Companies Need Simpler Terms of Servic… Top Reasons to Go With Managed WordPress Hosting Related Posts center_img dan rowinski A Web Developer’s New Best Friend is the AI Wai… HP founded a program called the “Zero Day Initiative” (ZDI) in 2005 designed to reward security professionals for responsibly reporting unknown vulnerabilities. Since 2005, Apple Quicktime has the most reported vulnerabilities with Microsoft Internet Explorer coming in second. Java, Firefox, Webkit, Real Player and Adobe (Shockwave and Reader) also make the list, along with HP OpenView. Those are some of the most fundamental technologies on the Web and their breadth contributes to the problem of enterprise security risks. HP notes that it does not really matter if there are new vulnerabilities or not. Malicious hackers already have an ample surface of attack with existing vulnerabilities. Patching, closing, fixing, debugging, replacing software, installing security measures or any other method that can be done to fix those vulnerabilities across the entire enterprise landscape would cost hundreds of millions if not billions of dollars. Yet, considering the volume of attacks keeps on increasing no matter how many vulnerabilities are reported, it behooves industries to attempt to get their networks up to do. See the chart below for mid-year attack totals from 2009-11. Tags:#security#web last_img read more

Google Plus Mobile Hangouts: It Pretty Much Works!

first_imgRelated Posts The Rise and Rise of Mobile Payment Technology jon mitchell Role of Mobile App Analytics In-App Engagement ReadWriteWeb’s Friday afternoon news team confirms that the Google Plus app for iPhone has been updated to incorporate this week’s new mobile features. The messaging service formerly known as Huddle has been renamed Messenger, and iPhone users now have the ability to join video Hangouts in progress.The update also adds some basic functionality, including the ability to +1 comments within threads and post directly to individuals instead of whole circles. It also provides more granular control over push notifications. Google’s social network left its “field test” phase and opened to the public this week. More from the news team, including images of Marshall Kirkpatrick blogging in the nude, after the jump.ReadWriteWeb’s Jon Mitchell (clothed), on Hangout with Marshall Kirkpatrick (nude)Both of our test pilots were on reasonably fast Wi-Fi, and the service still suffered from some lag, even though there were only two people on the Hangout. It cleared up, though, and Mitchell and Kirkpatrick were able to carry out a somewhat awkward and improperly dressed conversation. The interface is better suited to landscape mode than portrait; it fills up the screen, and the image of oneself can be dragged around the screen at will. The user can also flip to the main camera.It’s neat that mobile users can now join existing Hangouts, but they can’t create new ones. It’s also hard to imagine that existing mobile devices will be able to handle multi-user Hangouts, but it’s still very early for the Google Plus platform, and clearly these features are being built with future uses in mind. We’re not in the age of mobile video calling yet, but we’re getting there. Maybe by the time the iPhone 7G comes out in December.center_img Why IoT Apps are Eating Device Interfaces Tags:#Google#mobile#Product Reviews#web What it Takes to Build a Highly Secure FinTech …last_img read more

Marketo adds native ABM capabilities to its platform

first_imgMarketo adds native ABM capabilities to its platformYou are here: Posted on 14th September 2016Digital Marketing FacebookshareTwittertweetGoogle+share Marketing platform Marketo is jumping into Account-Based Marketing (ABM) with both feet today, unveiling what it says is the most comprehensive set of native functions on a major marketing platform.The new Marketo ABM allows marketers to target accounts — and decision-makers within those accounts — via personalized messages in emails, web, events, social media, mobile and ads on Google, Facebook and LinkedIn. The San Mateo, California-based company announced back in May that it intended to integrate ABM more tightly into its platform within the next few months.The core capabilities are being complemented by integrated functions offered in a new Marketo ABM ecosystem. Initial members include AdRoll, Bluewolf, Digital Pi, Dun & Bradstreet, Elixiter, EverString, Fathom, InsideView, LeadMD, Owler, Perkuto and PFL.“We’re not claiming we’re providing all of [needed] ABM capabilities,” Vice President of Product Marketing Mike Telem told me, adding that the platform probably offers 90 percent or more of what an ABM marketer might need at the beginning. If the marketer wants data enrichment solutions, for instance, they can add Dun & Bradstreet.Telem noted that, previously, Marketo offered its Web ABM, built on its acquisition in 2013 of Insightera. It was originally intended to be part of Marketo’s real-time web personalization capabilities but became a separate product. Web ABM, he said, was limited to websites, although it offered some ad capabilities and was “the equivalent of [ABM targeting platform] Demandbase.”By contrast, he said, the new ABM native capabilities were built “from the ground up,” and Web ABM has now become its web channel.New functions include targeting and messaging by account, engaging decision makers across channels, and measuring impact by account.Previously, he said, Marketo couldn’t orchestrate a cross-channel campaign for accounts and didn’t have the ability to link a person to an account automatically. That linkage is now made via domain names, IP matching, location and other attributes.Marketo is also treating accounts as an object in its system so an account can be scored as a lead might, based on engagement, profile and other factors. Predictive scoring can be added via integration with an outside provider.Treating an account as an object, he said, is typically in ABM-oriented point solutions but not in Marketo’s major marketing platform competitors. It permits an account dimension, so that attributes and data can be added and exported as an account.Among major competitors, Telem noted that Oracle’s Eloqua offers ABM capabilities largely through an integration with Demandbase, and Salesforce’s Pardot “doesn’t have that much ABM.”“Demandbase plus Eloqua is a decent comparison to what we’re doing,” he said, except Marketo’s is offered natively.I asked Telem why ABM has become such a hot area in recent months. He replied that it was partly because the technology has evolved to the point where ABM can be better managed. But, he added, it’s also because marketers have “gotten good at marketing at scale,” and the analytics are showing that account orientation offers a new level of opportunities.From our sponsors: Marketo adds native ABM capabilities to its platform HomeDigital MarketingMarketo adds native ABM capabilities to its platform Related postsLytics now integrates with Google Marketing Platform to enable customer data-informed campaigns14th December 2019The California Consumer Privacy Act goes live in a few short weeks — Are you ready?14th December 2019ML 2019121313th December 2019Global email benchmark report finds email isn’t dead – it’s essential13th December 20192019 benchmark report: brand vs. non-brand traffic in Google Shopping12th December 2019Keep your LinkedIn advertising strategy focused in 202012th December 2019last_img read more

Researchers Worldwide Rally to Help Scientist Exposed to Ebola

first_imgThe accidental exposure of a scientist to the Ebola virus last week has triggered a series of teleconferences by Ebola scientists on two sides of the Atlantic united around a single goal: to help save the life of their colleague, an unnamed virologist at the Bernard Nocht Institute for Tropical Medicine in Hamburg, Germany, who pricked herself in the finger during an experiment. No approved treatments exist for Ebola, but at the sessions, researchers and physicians discussed the results from a raft of recent studies, some not yet published, into treatments that could prevent or slow the disease, which has a mortality rate of up to 90%.In the end, the patient and her doctor opted not for an experimental drug but for a new type of living vaccine that has never been tested in humans but has been shown in monkeys to help fight the virus even when given after exposure. An injury from a virus-laden syringe often doesn’t lead to infection and disease, because the amount of virus entering the body is small. But the researcher’s doctors want to reduce the risk as much as they can.Today was the 6th day after the needle accident, and the small community of Ebola researchers has been anxiously following news about the researcher’s fate.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)She is currently doing well, says Stephan Günther, the head of virology at the Bernard Nocht Institute. But Ebola can have an incubation period anywhere between 4 and 21 days, which means she could still fall ill. In monkeys, the virus is usually detectable in the blood starting on day 3, 4, or 5, says Boston University virologist Thomas Geisbert, who has more experience than any other researcher with the virus in animals. That may be different in humans, Geisbert stresses, but still, “the chances that she’ll be okay are getting better every day.” Immediately after the researcher pricked herself last Thursday, Günther says he tried to assemble the best minds in the field. During a series of teleconferences–which included researchers from the Canadian Science Centre for Human and Animal Health in Winnipeg, the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) in Fort Detrick, Maryland, and the U.S. Centers for Disease Control and Prevention in Atlanta, Georgia–researchers discussed a long list of possible treatment options.The vaccine that eventually was picked was developed by Heinz Feldmann and his colleagues at the Winnipeg lab along with Geisbert, who tested it in macaque monkeys at USAMRIID. The vaccine is based on the vesicular stomatitis virus (VSV), a pathogen of cattle, horses, and pigs, whose glycoprotein has been replaced with that of Ebola. In 2003, the researchers showed that a single shot of the virus offers protection in monkeys (Science, 14 November 2003, p. 1141). A lot of time was spent last week debating the safety aspects of the vaccine; because it is a living virus that replicates inside its hosts, some worry that it could prove risky. And in contrast to another Ebola vaccine based on DNA, it has never been tested in humans. But its key advantage is that, at least in monkeys, it has been shown to offer protection even after exposure, says Günther. In a 2008 study, Feldmann and Geisbert showed that when given 20 minutes after a lethal shot of Ebola-Sudan, one of the five subtypes of the virus, half of the monkeys got sick, but all survived. With Ebola-Zaïre, the subtype to which the researcher in Hamburg was exposed, five out of eight monkeys survived the virus. In as-yet-unpublished work, the researchers also gave a vaccine against Marburg, a close cousin of Ebola, 1 or even 2 days after exposure, says Geisbert, and they found that it still offered partial protection. He expects the same will be true for the Ebola vaccine.Feldmann arranged shipment of the vaccine against Ebola-Zaire from Winnipeg the day the accident happened, and it reached the lab in Hamburg less than 48 hours after the accident, says Günther. (The researcher herself made the decision to have the vaccine, he says.) Meanwhile, a company called ARCA Biopharma, headquartered in Colorado, rushed to Hamburg a supply of an experimental anticoagulant drug called rNAPc2, which studies by Geisbert and colleagues have also shown to have promise against Ebola. But that has not been used so far, says Günther.After she received the vaccine, the researcher began running a fever. Because it was unclear whether this was due to the onset of Ebola or a reaction to the vaccine, she was placed in an isolation unit, shielded from the world by plastic, says Günther. The fever is gone now, and doctors would like to take her out of the unit and back into a normal hospital ward, says Günther. “Psychologically, the isolation is very difficult,” he says, and she could always be put back in should Ebola symptoms emerge. But the institute is “struggling a little” with Hamburg public health authorities reluctant to let the patient out, he says. Because so few Ebola cases occur in developed countries, there’s no consensus on the right precautions.The researcher was working on a study that involved mice, says Günther, who says he does not know the exact nature of the experiment. The last known lab exposure to Ebola, at USAMRIID in 2004, also involved mice. While a scientist tried to inject one of the animals using a hypodermic needle that had previously been used on other mice, researchers wrote in a 2008 paper about the case, “the animal kicked the syringe, causing the needle to pierce the person’s left-hand gloves, resulting in a small laceration.” That researcher did not become infected, however.last_img read more